許銘仁 教授 ( 主任 )
(Ming-Jen Hsu, Ph.D)

電話 | Tel02-27361661#3198
電子郵件 | E-mailaspirin@tmu.edu.tw
最高學歷 | Education台大醫學院 藥理學博士
研究專長 | Research Interests分子藥理、訊息傳遞、新藥(抗發炎與抗癌)開發
經歷 | Experience 臺北醫學大學藥理學科主任2020/8~
臺北醫學大學藥理學科教授2015/8~
臺北醫學大學藥理學科副教授2011/8~2015/7
研究計畫 | Research Projects
  • 新穎性長鍊烴基醯胺衍生物WMJ-J系列化合物之抗癌作用機轉探討(2016/08/01~2017/07/31)
  • 介白質-6促進大腸直腸癌進程之探討:上皮間質轉化與內皮間質轉化之角色(2015/08/01~2016/07/31)
  • 新穎長鏈烴基醯胺WMJ-S-001抑制大腸直腸癌進程之作用機轉:AMPK-p53 modification-miRNAs 訊息路徑之角色(2014/08/01~2015/07/31)
代表著作 | Research Paper
  • Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade. Sci Rep 2016
  • WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1. Oncotarget 2015 6:85-100.
  • The effects of a novel aliphatic chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Sci Rep. 2015 5:15900
  • WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in lipopolysaccharide-stimulated RAW264.7 macrophages Brit. J. Pharmacol. 2015 172:1894-1908
  • Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells. Biochem. Pharmacol. 2014 88:372-383
  • Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells. Angiogenesis. 2014 17:407-418
  • Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Biochim Biophys Acta-Gen. Subjects 2013 1830:4053-4064